C8

C8 columns have a wide range of applications in liquid chromatography (HPLC and UHPLC), particularly when a less retentive stationary phase than C18 is required or when working with highly nonpolar samples.

Key Applications:

• Separation of moderately nonpolar compounds: small lipophilic molecules where intermediate retention is desirable.

• Biological and pharmaceutical sample analysis: metabolites, drugs, and related substances that require lower retention to avoid long elution times.

• Separation of weak acids and bases: when lower retention than C18 is needed to prevent broad peaks or lengthy equilibration times.

• Protein and peptide chromatography: for methods requiring reduced nonspecific interactions with the stationary phase to maintain sample conformation and stability.

• Separation of extracts, plastics, or cosmetic-related compounds: hydrophobic compounds benefiting from an 8-carbon chain for balanced retention.

• Rapid method development and scaling: useful in method development (DoE) to compare C8 and C18 and determine the best resolution and analysis time.

• Separation of steroids and light lipids: some analytes with intermediate polarity benefit from the lower retention of C8 compared with C18.

• Methods under specific pH conditions: suitable when acidic pH conditions could deactivate or reduce interactions with the stationary phase, as C8 provides good inertness under acidic conditions.

Octylsilane Columns

HPLC (High Performance Liquid Chromatography) columns are the heart of the high-resolution liquid chromatography system.

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